More on Genetic Predisposition to Nicotine Dependence

Nicotine junkies can now be free from remorse since their cravings for nicotine are, in fact, a genetic disease. A group of American scientists representing the University of Michigan, the University of North Carolina and Washington University School of Medicine have confirmed the hypothesis that nicotine addiction can originate on a genetic level.

More precisely, they found a genetic configuration typical for nicotine-dependent individuals. Unfortunately, the same genetic variant can be involved in triggering lung cancer, the scientists reported in the latest issue of the journal Addiction.

Those who have the nicotine-sensitive genetic configuration tend to enjoy their first smoking experience. They are also much more likely to become hooked on tobacco for life, says lead author of the research professor Ovide Pomerleau.

The study also focused on investigating possible solutions in treating genetically-based nicotine addiction. Every year, over 400,000 people fall victims of their smoking habit, succumbing to lung cancer, severe infections, and other devastating diseases directly caused by tobacco smoke.

In the study, the scientists looked at possible connections between the gene CHRNA5 that is believed to be responsible for nicotine addiction and smoking patterns of the participants. Total of 435 adults, both smokers and non-smokers, took part in the research.

As a result, the researchers found that non-smoking participants without the gene in question, although had tried cigarettes at least once during their lifetime, had not become dependent on tobacco. They also reported a negative reaction to their initial tobacco smoke exposure. On the other hand, established smokers, especially those who had enjoyed their first cigarette and quickly become addicted to nicotine, have showed a much higher occurrence of the gene CHRNA5.

Individuals with the nicotine- addictive genetic makeup are highly susceptible to become life-long smokers, says Dr. Pomerleau. They also tend to enjoy their first and subsequent smoking experiences much more than people without the genetic variant.

However, genetic predisposition is only one part of smoking addiction, point out the researchers. Environmental and social factors, such as availability of tobacco products, peers’ pressure, fashions, traditions, and cultural trends can play a significant role in the individual’s decision to become and remain a smoker.

Hopefully, these recent findings of the American scientists will help in developing new approaches and medications to successfully treat nicotine dependence.

Darlene Marlow

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